Plant estrogens, or phytoestrogens (PEs), are naturally occurring compounds found in plants that are similar to estrogenic hormones. Epidemiological evidence indicates that dietary PEs may provide protection from the development of some cancers, cardiovascular disease, osteoporosis, and menopausal symptoms. Dietary PEs are absorbed from the intestines, detected in the blood and urine of humans and animals, and excreted in the urine and feces. PEs bind to estrogen receptors on cells and exert a weak estrogenic effect that is 100-1000-fold less than estradiol or estrone, the principal circulating estrogens of most mammals. PEs act to inhibit cancer cell growth in intact animals by binding to and occupying estrogen receptors on cancer cells, thus blocking cancer cell stimulation by natural estrogens. They also exert an anticancer effect in animals by non-estrogen receptor-mediated mechanisms, which either decrease estrogen production and/or bioavailability or inhibit cancer cell proliferation and tumor invasion. Dietary PEs appear to be protective against breast, prostate, and intestinal cancers. They also act to lower blood cholesterol and inhibit lipid peroxidation, which are primary factors in cardiovascular disease. Additionally, PEs appear to ameliorate estrogen-deficiency symptoms, such as hot flushes and osteoporosis, in postmenopausal women. Based on recent reviews of the scientific literature, no human data suggest that PEs in the diet are harmful at any age.
To consumers, the basic building blocks of nutrients are well known: essential amino acids, essential fatty acids, vitamins and minerals. What Mannatech has discovered is a brand new category of important nutrients: glyconutrients. Following their initial breakthrough discovery, Mannatech filed patents across the globe. Ambrotose® complex has now been issued patents in 29 countries, including the
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